As an expert in providing solutions to assist virology and microbiology research, Creative Diagnostics is proud to announce the launch of its innovative Influenza A Virus Mouse Models to assess the impact of virus-host interactions. These mouse models can facilitate comprehensive research into the pathogenesis, immune response, and efficacy of antiviral treatments against influenza A infections.
Influenza A viruses are members of the Orthomyxoviridae family with a unique genome consisting of eight single-stranded negative-sense RNA fragments. These viruses have two major surface antigens, hemagglutinin (HA) and neuraminidase (NA), which determine the antigenicity of the virus. With 18 known HA subtypes (H1-H18) and 11 NA subtypes (N1-N11), influenza A viruses pose a challenge to global health, particularly seasonal subtypes such as H1N1 and H3N.
Influenza A viruses exhibit a remarkable ability to mutate and evolve, producing multiple subtypes and antigenic variants. These variations are driven by RNA polymerase as it replicates the viral genome. In addition, when different subtypes infect the same host cell, genetic recombination occurs between them to further generate new strains of the virus. This dynamic nature of influenza A viruses requires regular updating of the immunogenic components used to combat the disease.
Creative Diagnostics’ research team takes advantage of mouse models to study a variety of influenza A virus strains, including H9N2, H1N1 and H3N2. The portfolio offers customized and standard preclinical services to evaluate pathogenesis, humoral responses, and protective efficacy induced by wild-type influenza A viruses or influenza vaccines using mouse infection models. Mouse models offered by Creative Diagnostics include but are not limited to H9N2 Avian Influenza Mouse Model, H1N1 Mouse Model, Pdm H1N1 Mouse Model and H3N2 Mouse Model.
Creative Diagnostics specializes in providing state-of-the-art mouse models of influenza A virus that allow comprehensive assessment of the impact of test compounds on the pathogenicity and transmissibility of influenza A strains. These innovative mouse models provide valuable insights into virus-host interactions, revealing transmission dynamics and the impact of influenza A on morbidity and mortality. Additionally, Creative Diagnostics provides valuable data on viral disease progression, histology, immunohistochemistry, immunoassays, flow cytometry, cellular infiltration, cytokines, viral titers, LD50 studies, and vaccine/treatment efficacy.
These mouse models of influenza A virus can also be used to evaluate different classes of therapeutic agents such as antivirals, anti-inflammatory drugs and pulmonary therapeutics, and to study viral pathogenesis and humoral responses in mice infected with influenza A virus. With carefully selected and bred mouse strains, researchers can select the most appropriate model to continue their influenza A virus-related research.
By providing researchers with reliable and versatile tools, Creative Diagnostics aims to accelerate the development of effective strategies to combat influenza A infections. To learn more about these new animal models and other products from Creative Diagnostics, please visit https://antiviral.creative-diagnostics.com/influenza-a-virus-mouse-model.html.
About Creative Diagnostics
Headquartered in New York, Creative Diagnostics is a consulting and experimental service provider specializing in virology and microbiology. The company provides comprehensive solutions to conquer obstacles in virology and microbiology research, from high-security infrastructure provision, biosafety regulation elucidation, to expert viral system assistance.
Author: Thomas Schmitt
Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. In addition to providing contract R&D and biologic manufacturing services for diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market, the company aims to continue to act as a trusted source for all researchers’ assay development and manufacturing needs.
