If you’re unaware of your pregnancy, morning sickness indicates that you’re pregnant, and you should confirm your pregnancy. The mild symptoms of nausea and vomiting can be acceptable and go away when you enter your second trimester. Sometimes these symptoms are severe and can cause adverse pregnancy outcomes. Zofran is the best drug to treat nausea and vomiting. Now the question is, can I use Zofran during pregnancy to treat morning sickness! Let’s discuss!


What is Zofran?

Zofran (brand name of ondansetron) is prescribed to reduce the severity of nausea and vomiting symptoms due to cancer treatment. Ondansetron is the most effective and has also been approved by Food and Drug Administration (FDA) drug to control nausea & vomiting symptoms for years. The way Zofran works is by blocking the effects of serotonin. Serotonin is a valuable hormone and neurotransmitter that optimizes functions like appetite, mood, social behavior, digestion, etc.

This drug is also used to relieve nausea and vomiting caused by radiation therapy, anesthesia, and surgery. Zofran is getting popularity, also prescribed to pregnant women to treat morning sickness because of its potential work to overcome vomiting and nausea symptoms.


Can you take Zofran while pregnant?

More than 80% of females are affected by morning sickness during the first trimester. Most women may go through mild symptoms of nausea and vomiting that dietary and lifestyle changes can treat. This means avoiding heavy meals, processing food, and taking dried ginger and saltine.

On the other hand, some females (0.3 – 3.0%) may get severe symptoms of morning sickness known as hyperemesis gravidarum and require proper treatment. Therefore, doctors recommend Zofran to pregnant females to get relief from morning sickness. Doctors are conflicted regarding their use during pregnancy because they are neither approved by FDA nor completely safe for you and your baby.

Further studies show that taking Zofran during the first trimester is less likely to cause significant birth defects. According to CDC research, if your baby exposes to Zofran during pregnancy, there are chances of developing heart defects and cleft palates. Additionally, in 2011, the FDA warned that using Zofran during pregnancy may increase the risk of maternal heart problems.

On the other hand, if the disease is left untreated can lead to severe metabolic changes, resulting in nutritional dearth and increasing the risk of malformations, eventually, a loss of pregnancy. Furthermore, severe and prolonged symptoms of morning sickness may increase the risk of anxiety and depression symptoms. The combination of these multiple factors can cause the end of your pregnancy.

When this type of situation arises, taking medication is mandatory but has risks. This can be addressed; if the effect of taking medication is less than left the disease untreated. It would be best if you prefer to take Zofran.

Another very important supplement that women tend to take while pregnant is folic acid and L-methylfolate. Both of these supplements are very popular nowadays and typically recommended by doctors. Both of a large number of benefits for pregnant women. Few women know what the difference is between folic acid versus L-methylfolate. We highly recommend that you talk to your doctor and find out what is right for you before taking any supplements.


Side effects of Zofran

No doubt, side effects are always associated with medications. Likewise, side effects from Zofran can be;

  • Tiredness
  • Weakness
  • Dizziness
  • Headache
  • Diarrhea
  • constipation

Don’t take Zofran on its own. Although doctors are commonly prescribed Zofran, its safety during pregnancy is conflicted. If your doctor prescribes this medication, then take it. You can also take vitamin b6, dopamine antagonists, and doxylamine to reduce the symptoms of vomiting and nausea.


Most pregnant women go through Morning sickness during their first trimester. The majority of them recovered as their first trimester ended. But in some women, the symptoms of morning sickness become worse and prolonged, leading to the end of pregnancy if not treated. Thus, doctors advised pregnant women to take Zofran to treat morning sickness. But its safety regarding its use during pregnancy is under discussion.





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